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In the direction of investigate the population pharmacokinetics of daunorubicin in children after administration of liposomal daunorubicin Daunoxome. Plasma samples from 19 children by means of relapsed acute myeloic leukaemia and five children including other malignancies were unexcited.

Daunoxome was administered like a 1- to 2. Overall, samples were analysed for daunorubicin using duct electrophoresis, and population pharmacokinetic modelling was performed using NONMEM. The data were best described by a one compartment model. Enclosure of interoccasion variability participate in the model The inclusion of body get out area or height because a covariate decreased interindividual variability. However, the unsurpassed fit was obtained using the absolute dose, also when weight was incorporated as a covariate representing clearance CL and amount of distribution V.

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  • AIMS: To investigate the population pharmacokinetics of daunorubicin in children after administration of...
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How is this medicine DaunoXome best taken? Use with DaunoXome daunorubicin liposomal may either raise the chance of an infection or make the vaccine not work as well. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.
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